Influence of integrin-binding motif (RGD) on attachment and internalization of avian adenovirus CELO in mammalian cells
Zubkova, O.V.; Logunov, D.I.; Karpov, A.P.; Shmarov, M.M.; Belousova, R.V.; Naroditskiĭ, B.S.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 2: 32-36
2008
ISSN/ISBN: 0208-0613 PMID: 18488447 Document Number: 622090
Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that introduction of RGD-motif into fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised efficiency of the process of internalization of the virus both in CAR-positive, and in CAR-negative cells.