Heparin binding haemagglutin as potential diagnostic marker of Mycobacterium bovis
Molicotti, P.; Bua, A.; Ortu, S.; Ladu, M.C.; Delogu, G.; Mura, A.; Sechi, L.A.; Fadda, G.; Zanetti, S.
New Microbiologica 31(3): 423-427
2008
ISSN/ISBN: 1121-7138 PMID: 18843899 Document Number: 620079
In this study, we characterized the humoral responses in cattle of Sardinia. The animals were divided into three groups: (1) 28 cattle infected with Mycobacterium bovis; (2) 48 cattle from herds in which foci of infection was notified; (3) 50 cattle from herds that were TB-free. Levels of IgG antibody were measured against the following antigens of M. tuberculosis: Heparin-Binding-Haemagglutin (HBHA), Ag85B, PPE44, and PE_PGRS33 to investigate their potential to diagnose TB in animals.