Hemostatic disorders in liver disease
Mitrică, D.; Drug, V.L.; Prelipcean, C.C.; Stan, M.ăr.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 112(2): 313-320
2008
ISSN/ISBN: 0048-7848 PMID: 19294997 Document Number: 618881
Hemorrhagic complications are common in patients with liver diseases and contribute to the morbidity and mortality associated to this condition. The liver plays a central role in the hemostatic process as here all clotting factors and their inhibitors are synthetized. Liver damage is commonly associated with variable impairment of hemostasis due to multiple causes: decreased synthesis of clotting and inhibitor factors, decreased clearance of activated factors, hyperfibrinolysis, accelerated intravascular coagulation, quantitative and qualitative platelet defects. Their clinical implications remain to be elucidated, so further studies addressing this issue are needed.