Non-specific stress-reaction as indicator of radiosensitivity
Hanzha, O.B.; Rodionova, N.K.; Dolyns'kyĭ, H.A.; Kostiukova, L.V.; Druzhyna, M.O.
Fiziolohichnyi Zhurnal 54(6): 72-78
2008
ISSN/ISBN: 2522-9028 PMID: 19227243 Document Number: 617995
The data presented demonstrate possible personal radiosensitivity prognosis according to the immobilization stress response (animal model). It was demonstrated on the Wistar rats that in radiosensitive animals initial oxidative metabolism parameters were higher than in radioresistant ones, and prooxidant-antioxidant balance alteration after non-radiation stress were more evident and kept for a longer period. Those animals had had limphopenia and neutrophilosis. The differences in the response types between radiosensitive and radioresistant animals were due to the blood system reserve abilities, as well as the state of natural mature cells depot, and antioxidant defence enzymes.