Concentration of benzylpenicillin sodium salt in the cerebrospinal fluid of patients with late neurosyphilis as an indicator of efficacy of specific therapy
Rodikov, M.V.; Rudnev, V.A.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 109(5): 27-31
2009
ISSN/ISBN: 1997-7298 PMID: 19491815 Document Number: 633193
A permeability of crystallized benzylpenicillin sodium salt (CBSS) through a blood-brain barrier (BBB) in patients with late neurosyphilis and experimental animals has been studied. Forty-six patients with vascular and late meningovascular neurosyphilis have been examined. A group of experimental animals included 50 rabbits. The injection of CBSS to patients and animals was followed by the measurement of antibiotic's concentration in the cerebrospinal fluid (CSF) using high performance liquid chromatography. The level of CSF penicillin concentration was estimated as an indicator of efficacy of the treatment. The treponemocide concentration of antibiotics in the CSF was reached only in patients with meningovascular neurosyphilis (0.029+/-0.003 mcg/ml; p<0.05). There was an increase of BBB permeability for CBSS and concentration of the latter in CSF from 0.0012+/-0.001 mcg/ml to 0.02+/-0.0012 mcg/ml (p<0.05) after the injection of mannitol in rabbits.