Proton magnetic resonance spectroscopy in postoperative radiochemotherapy of patients with cerebral glioblastoma
Pozdniakov, A.V.; Kartashev, A.V.; Tiutin, L.A.; Vinogradov, V.M.; Pozharisskiĭ, K.M.
Voprosy Onkologii 54(2): 164-169
2008
ISSN/ISBN: 0507-3758 PMID: 18522164 Document Number: 617937
The paper discusses the data from dynamic follow-up of immunohistologically confirmed glioblastomas of the brain using proton magnetic resonance imaging (+H MRI) (25). Study was undertaken before and after therapy and resumed for 6-8 months after. Cholin concentration peaks and N-acetyl-aspartate decrease in gliomas appeared to be higher than those in anaplastic astrocytomas. Moreover, N-acetyl-aspartate peaks were obliterated by large necrotic areas in glioblastoma. Instead, lipid and lactate concentrations peaked thus suggesting pathological changes. A necrotic area developed in the course of radiochemotherapy involving peaks for wide profile of lipid and lactate concentrations coupled with lowered levels of other metabolites.