Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis
Bertinotti, L.; Mortilla, M.; Conforti, M.Letizia.; Colangelo, N.; Nacci, F.; Del Rosso, A.; Fonda, C.; Casale, R.; Matucci-Cerinic, M.; Pignone, A.
Journal of Rheumatology 33(3): 546-551
2006
ISSN/ISBN: 0315-162X PMID: 16511924 Document Number: 595680
Objective. Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy (H-1-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc.Methods. N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (ISSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects.Results. With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p < 0.02) and at RCS (p < 0.002) was detected in SSc patients. Cho/Cr ratio was increased (p < 0.02) in the RCS, but not in RBG. In patients with ISSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG.Conclusion. Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc.