Transient hyperphosphatasemia in an infant with bronchiolitis and pneumonia
Dodig, S.; Demirovic, J.; Jelcic, Z.; Richter, D.; Cepelak, I.; Zrinski Topic, R.; Petrinovic, R.
European Journal of Medical Research 13(11): 536-538
2008
ISSN/ISBN: 0949-2321 PMID: 19073391 Document Number: 617680
We present a case of benign transient hyperphosphatasemia in a 4-month-old infant with acute bronchiolitis and pneumonia. During hospitalization the infant had an increased catalytic activity of alkaline phosphatase (ALP): day 2, 5074 U/L; day 3, 5622-U/L; and day 8, 3129 U/L. The x-ray, leukocytosis, and C-reactive protein findings pointed to bacterial etiology of the respiratory disorder. Electrophoretic separation revealed an atypical isoenzyme profile: fast anodal, near-cathodal and bone fractions. ALP levels normalized within 54 days, and control electrophoresis indicated normal liver, placental/placental-like, intestinal and bone isoenzymes. The appearance of atypical fast anodal and near-cathodal fractions of ALP in this infant during the course of acute lower respiratory tract infection and rapid return to the reference intervals pointed to benign transient hyperphosphatasemia.