Influence of JDTL injection on inflammatory factors in rat experimental cerebral ischemia
Yang, H.; Zhao, Y.-j.; Wang, Y.-y.
Zhongguo Zhong Yao Za Zhi 33(23): 2817-2820
2008
ISSN/ISBN: 1001-5302 PMID: 19260320 Document Number: 617679
To stydy the protective mechanism of Jiedu Tongluo (JDTL) injection on experimental cerebral ischemia. Radioimmunoassay (RIA) was utilized to identify the content of TNF-alpha and IL1-beta in brain tissue of rats suffered from 6 h and 24 h ischemia with MCAO, Enzyme-linked immunoadsordent assay (ELISA) was used to observe the level of MCP-1 and ICMA-1. After 6 h and 24 h of ischemia, the increased contents of TNF-alpha, IL1-beta, MCP-1 as well as ICMA-1 was observed. JDTL injection dramatically inhibited the increase of TNF-alpha, IL1-beta after 6 h and 24 h of ischemia. JDTL injection had inhibiting effect on TNF-alpha, IL1-beta, MCP-1 as well as ICMA-1 caused by cerebral ischemia, the result suggested that JDIL injection can protect cerebral tissue from ischemic injury by inhibiting inflammatory factors.