Enhanced oral bioavailability of salvianolic acid B by phospholipid complex loaded nanoparticles
Peng, Q.; Gong, T.; Zuo, J.; Liu, J.; Zhao, D.; Zhang, Z.
Die Pharmazie 63(9): 661-666
2008
ISSN/ISBN: 0031-7144 PMID: 18819519 Document Number: 617233
Salvianolic acid is one of the phenolic acids found in Danshen, a well-known traditional Chinese medicine consisting of the dried roots of Salvia miltiorrhiza. With a simple and feasible method, a salvianolic acid B-phospholipid complex was prepared to increase the absorption of salvianolic acid B in the gastrointestinal (GI) tract of rats. Because the solubility of the complex in water was very poor, the complex was encapsulated into nanoparticles to facilitate its administration.
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