A liposomal delivery vehicle for the anticancer agent gossypol
Zhai, G.; Wu, J.; Zhao, X.; Yu, B.; Li, H.; Lu, Y.; Ye, W.; Lin, Y.C.; Lee, R.J.
Anticancer Research 28(5a): 2801-2805
2008
ISSN/ISBN: 0250-7005 PMID: 19035313 Document Number: 617232
Gossypol has recently been identified as a potential anticancer agent. In this study, a novel liposomal formulation is evaluated for delivery of gossypol. Gossypol was incorporated into liposomes. The liposomes were characterized for physical and chemical properties and for in vitro cytotoxicity. Gossypol was stably encapsulated in these liposomes and exhibited cytotoxicity towards cancer cells. Liposomes can be used effectively as gossypol carriers.