The regulatory T-cell phenotype in progressive mycosis fungoides
Hallermann, C.; Schulze, H.-J.; Neumann, C.; Klemke, C.-D.
Giornale Italiano di Dermatologia e Venereologia Organo Ufficiale Societa Italiana di Dermatologia e Sifilografia 143(1): 15-19
2008
ISSN/ISBN: 0392-0488 PMID: 18833048 Document Number: 616102
In early stages mycosis fungoides (MF) often runs an indolent course. Nevertheless a small but significant part of these patients develop an aggressive, life threatening course. These patients usually were immunocompromised. In most of those cases the lymphoma cells express CD25. This raised the question if those lymphomas may express a regulatory phenotype. Recently a couple of in vitro and in vivo studies analyzed this issue with different methods. This review discusses the recent developments in this highly topical area of research.