Granulomatous mycosis fungoides with large cell transformation misdiagnosed as leprosy

Siriphukpong, S.; Pattanaprichakul, P.; Sitthinamsuwan, P.; Karoopongse, E.

Journal of the Medical Association of Thailand 93(11): 1321-1326

2010


ISSN/ISBN: 0125-2208
PMID: 21114213
Document Number: 12795
Granulomatous mycosis fungoides is an unusual histopathological variant of cutaneous T-cell lymphoma without clinical distinction from classic mycosis fungoides. Symptoms associated with peripheral nerve involvement have rarely been reported in the literature. The authors described a case of granulomatous MF stage IIB with large cell transformation who initially presented with leprosy-like condition and chronic left peroneal neuropathy The patient received six courses ofgemcitabine with greater than 90% improvement of skin lesions. The rest of the lesions were successfully treated with local electron beam radiation. Granulomatous MF with neuropathy can be clinically misdiagnosed if there is no histopathological and immunohistochemical finding to support the diagnosis of lymphoma.

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Granulomatous mycosis fungoides with large cell transformation misdiagnosed as leprosy