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Long-term disorders in the rat behaviour induced with introduction of the tumour necrosis factor in early postnatal ontogenesis

Zubareva, O.E.; Klimenko, V.M.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 94(1): 14-19

2008

ISSN/ISBN: 0869-8139
PMID: 18383727
Document Number: 615133
Anti-inflammatory cytokin the tumour necrosis factor alpha (TNFalpha) is one of the main mediators of neuroimmune interactions. The TNFalpha production increase in the cells of neural and immune systems occurs in infectious diseases, injuries, ischemia, hypoxia. In this study, the TNFalpha revealed its role in formation of behaviour in early postnatal ontogenesis. The rats with the TNFalpha administered during their 3 weeks of life differed from the control those by a change in the orienting behaviour and enhanced anxiety. The role of the anti-inflammatory cytokins in the brain during different stages of ontogenesis is discussed.

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