The action of proinflammatory cytokines on formation of behavior during early postnatal ontogenesis
Zumareva, O.E.; Eliseeva, A.P.; Simbirtsev, A.S.; Klimenko, V.M.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 91(4): 374-384
2005
ISSN/ISBN: 0869-8139 PMID: 15969437 Document Number: 584935
The study is devoted to the role of proinflammatory cytokine-interleukin-1beta during early postnatal ontogenesis in formation of behavioral programs. Cytokine was injected in pyrogenic and subpyrogenic doses during 1 week (1, 2 or 3 weeks of life). The behavior was tested in the young (40-45 days) and adult (3 months) rats in the "open field" and "elevated plus maze". The greatest behavior disordes (elevation of act's number and of motor activity, the decrease of investigation activity) are revealed in the young animals treated with IL-Ib during 1 and 3 weeks of life. These behavioral changes were marked in rats injected with pyrogenic and subpyrogenic doses of cytokine. They had a similar tendency in male and female rats. At the age of 3 months, behavior changes revealed in juvenile rats were insignificant.