Serum lipids as biochemical manifestations of hepatic alcoholic, viral, and mixed viral-and-alcoholic lesion
Makarov, V.K.; Khomeriki, S.G.
Klinicheskaia Laboratornaia Diagnostika 5: 17-19
2007
ISSN/ISBN: 0869-2084 PMID: 17665613 Document Number: 614635
The parameters of lipids, which reflect the morphological manifestations of hepatic damages of alcoholic, viral, and mixed viral-and-alcoholic genesis, were determined. The serum lipid spectrum was studied in 50 alcoholic patients without viral hepatitis markers, in 30 patients with chronic viral hepatitis B (CVHB), and in 40 with CVHB concurrent with alcoholism. Puncture biopsy of the liver and a histological study of its biopsy specimen were made in 47 patients. Total lipid levels above 9.0 g/l were the most typical biochemical marker of alcoholic damage to the liver; lysophosphatidylcholine (LPC) levels below 7% were a marker of its viral damage; total lipid levels above 9.5 g/l and LPC levels below 5% were a marker of its viral-and-alcoholic damage. Thus, serum lipids may be used as biochemical markers of the morphological manifestations of hepatic damages of various genesis.