Pharmacokinetics of antipyrine in viral and alcoholic lesions of the liver
Tsyrkunov, V.M.; Bushma, M.I.; Garelik, P.V.; Novitskiĭ, G.K.; Zavodnik, L.B.
Klinicheskaia Meditsina 67(2): 87-89
1989
ISSN/ISBN: 0023-2149 PMID: 2724896 Document Number: 328190
Parameters of antipyrine pharmacokinetics have been studied in 82 patients with viral, alcoholic and combined liver affections and in 19 healthy subjects. All the patients exhibited changes showing a reduction of liver function responsible for drug metabolism. Disturbances of antipyrine pharmacokinetics were more pronounced in acute alcohol-aggravated hepatitis B than in hepatitis B without alcoholic aggravation.