Pharmacokinetics of antipyrine in calves at neonatal period fed with casein supplemented food
Janus, K.
Archivum Veterinarium Polonicum 34(3-4): 287-296
1994
ISSN/ISBN: 1230-5359 PMID: 8891183 Document Number: 429635
Hepatic biotransformation rate (evaluate using the pharmacokinetics of antipyrine ) was examined in neonatal calves given supplementary casein. A 25% increase in protein content in rations significantly increased hepatic biotransformation rate (activity of monooxygenases dependent on cytochrome P-450). The results indicate that a protein-rich diet may significantly increase metabolism of other xenobiotics via the mixed function oxidase/cytochrome P-450 enzymatic system.