Effect of dimethoate on dopamines neurotransmitters in brain regions of rat
Ruan, G.; Wu, Q.'e.; Wu, Q.; Zheng, L.
Wei Sheng Yan Jiu 36(1): 5-8
2007
ISSN/ISBN: 1000-8020 PMID: 17424836 Document Number: 613582
To observe changes of dopamine and its metabolite (3,4-hydroxyphenylaceticacid, DOPAC) levels of the brain regions in rats exposed by dimethoate (DM). Groups of rats were treated with saline and 38.9, 83.7 and 180.0 mg/kg DM respectively, and were decapitated at different time course from 0.5 to 24 hours after the administration. The dopamine neurotransmitters and its metabolite were determined by reverse-phase high-performance liquid chromatography with electrochemical detection. The concentrations of DA (28% - 122% of control) and DOPAC (89% - 538% of control) varied according with the DM dose and the exposure time. These results indicated that DM-induced toxic effects could alter the dopamine levels after the different dose and time exposure in the brain regions of rats.