Two types of NP-NP associations in influenza virus-infected cells
Semenova, N.P.; Chumakov, V.M.; Grigor'eva, T.A.; Rudneva, I.A.; Burov, V.V.; Prokudina, E.N.
Voprosy Virusologii 52(3): 9-12
2007
ISSN/ISBN: 0507-4088 PMID: 17601043 Document Number: 608736
Two types of NP-NP associations are shown to form in the influenza virus-infected cells. Early NP synthesis gives rise to NP associations stabilized by relatively weak bonds. These structures are designed as NP multimers. The high protease- and heat-sensitivities allow NP-multimers to be regarded as incompletely folded proteins. Posttranslational ly, NP-multimers transform to compact NP associations (NP oligomers) that are relatively highly heat- and protease-resistant. The NP-multimers untransformed to the folded compact NP-oligomers accumulate in the cells and partially degraded. Whether both types of NP-NP associations may be of significance is under discussion.