The influence of coordinational germanium compounds on the activity of glycosidases
Varbanets, L.D.; Rzaeva, O.N.; Avdiiuk, E.V.; Seĭfullina, I.I.; Martsinko, E.E.; Pesaroglo, A.G.
Mikrobiolohichnyi Zhurnal 69(3): 11-18
2007
ISSN/ISBN: 0201-8462 PMID: 17682526 Document Number: 608259
The ability of the synthesized compounds of germanium with bioligands to affect the biosynthesis and activity of alpha-amylase and alpha-L-rhamnosidase has been studied. It was established the most complexes tested induced biosyntheis of alpha-amylase of Bacillus subtilis 147 (119-252%) with the exception of Pam (Pyracetam) and II (Ge-nicotinic-citric acid). At the same time the biosynthesis of alpha-amylase of Bacillus licheniformis 234 and alpha-L-rhamnosidase of Penicillium commune was inhibited by a number of synthesized compounds. The complexes IV (Ge-malonic acid) and VIII (Ge-nicotinamide-malonic acid) did not exert any effect on the biosynthesis of alpha-amylase however complex IV stimulated alpha-L-rhamnosidase biosynthesis on the 3rd day of producer cultivation. The study of influence of the studied germanium compounds on the activity of alpha-amylase and alpha-L-rhamnosidase gives every reason to suppose that they are the inhibitors of the above-mentioned enzymes.