Cerebral infarction, a complication of paroxysmal nocturnal haemoglobinuria
Billot, S.; Mouton, A.; Lhote, F.; De-Broucker, T.
Revue Neurologique (Paris) 163(1): 138-141
2007
ISSN/ISBN: 0035-3787 PMID: 17304183 Document Number: 608219
Paroxysmal nocturnal hemoglobinuria (Marchiafava-Micheli disease) is a rare acquired clonal disorder of the hematopoietic stem cell. its most frequent clinical manifestations are hemolytic crisis and the most serious are venous thrombosis of the mesenteric, hepatic, portal or cerebral territories. Arterial cerebral infarctions are extremely rare. We report and comment on a case of multiple strokes occurring during an hemolytic crisis and despite effective long-term anticoagulation treatment.