Thrombosis of the portal vein as a complication of paroxysmal nocturnal hemoglobinuria
Nicolás, J.M.; Cervantes, F.; López-Guillermo, A.; Quinteros, L.; Rozman, C.
Revista Clinica Espanola 187(6): 287-289
1990
ISSN/ISBN: 0014-2565 PMID: 2091093 Document Number: 349033
A patient suffering nocturnal paroxysmal hemoglobinuria (HPN) associated with the recovery phase of a severe medullar aplasia, and who presented a thrombosis of the portal vein is described. The sudden appearance of fast growing splenomegaly with signs of hypersplenism was the sign that made us suspect of a portal thrombosis. The diagnosis was confirmed by an ultrasound and an angiographic study with DIVAS. The problems due to the thromboembolic complications of HPN are reviewed and the therapeutic possibilities are discussed.