Effect of charge and size of diffusing probe on the diffusion through calcium alginate gel matrices
Holte, Ø; Tønnesen, H.H.; Karlsen, J.
Die Pharmazie 62(12): 914-918
2007
ISSN/ISBN: 0031-7144 PMID: 18214342 Document Number: 607828
The diffusion of latex particles and low molecular weight fluorescein analogues in homogenous, well-defined calcium alginate gel matrices was studied. The experimental results indicate that the different types of diffusion probes are retarded by different mechanisms in the gel. The positively charged low molecular weight substance experienced some degree of retardation by the gels, but the diffusion rate of the uncharged low molecular weight substance was little influenced by gel composition. A wide range of diffusion rates was observed for the particles in the various gel compositions.