Two system-size-resonance behaviors for calcium signaling: for optimal cell size and for optimal network size
Hou, Z.; Zhang, J.; Xin, H.
Physical Review. E Statistical Nonlinear and Soft Matter Physics 74(3 Part 1): 031901
2006
ISSN/ISBN: 1539-3755 PMID: 17025661 DOI: 10.1103/physreve.74.031901Document Number: 393798
We have studied the collective calcium signaling behavior of an array of coupled N cells, taking into account the internal noises resulting from the small cell size V. The system's performance was characterized by the reciprocal coefficient of variance (RCV) of the calcium spike train. Two system-size resonances were observed, namely, the RCV value shows a clear peak when both N and V are optimal. Therefore, an optimal number of cells of optimal size work the best as a whole.