The molecular-genetic study of juvenile endogenous attack-like psychoses
Golimbet, V.E.; Kaleda, V.G.; Alfimova, M.V.; Korovaĭtseva, G.I.; Lavrushina, O.M.; Barkhatova, A.N.; Kasparov, S.V.; Ivanova, N.V.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 107(8): 49-54
2007
ISSN/ISBN: 1997-7298 PMID: 18379473 Document Number: 606767
Polymorphisms of the following genes (dopamine receptors D2 (Taq1A), D3 (Ser/Glu), D4 (VNTR, -521T/C, -616 G/C, -809A/G), catechol-O-methyltransferase, serotonin receptor type 2A (T102C), serotonin transporter (5-HTTLPR small i, Cyrillic VNTR) and brain-derived neurotrophic factor) have been studied in 260 men with juvenile endogenous attack-like psychoses and 145 age- and sex-matched controls. Type of psychopathological syndrome, PANSS scores and cognitive traits have been assessed. Only the T102C 5-HTR2A polymorphism was associated with some changes in the progress of this type of psychosis. As compared to the TT genotype, patients with 1 or 2 copies of the C allele were characterized by the absence of or less pronounced affective symptoms and more cognitive impairment that implies severity of illness. Moreover, the higher frequency of the C allele was found in the group of patients with chronic course of disease. In conclusion, the T102C polymorphism can be taken into account in prediction of juvenile endogenous attack-like psychosis.