Polymorphic variants of a surfactant protein C gene in patients with chronic obstructive pulmonary disease
Tsvetkova, O.A.; Veselovskaia, M.V.
Terapevticheskii Arkhiv 79(9): 65-69
2007
ISSN/ISBN: 0040-3660 PMID: 18038590 Document Number: 606592
Aim. To investigate effects of polymorphic variants of surfactant protein C gene (SFTPC) on the course of the disease in patients with chronic obstructive pulmonary disease (COPD).Material and methods. Sixty COPD patients were examined with COPD of stage 0-IV. The following parameters were studied: smoking index (SI), bronchial patency, lung pathology by the findings of high resolution computed tomography, polymorphisms of SFTPC gene by the data of polymerase chain reaction (PCR) followed by mass-spectrometric detection. A trend was found to correlation between a polymorphic variant of A138C and COPD severity (p = 0. 056). A CC genotype occurred more frequently in patients with COPD stages III and IV. A significant correlation exists between a polymorphic variant of A186G and the disease course severity (p = 0.23). Genotypes AA or AG are more typical for patients with COPD stage 0, 1 and II; GG genotype - stage III and IV. Genotype CC SFPTC A138C and genotype GG SFTPC A186G are significantly associated with pulmonary emphysema (p = 0. 004 and p = 0. 01, respectively).Conclusion. Polymorphic variants of SFTPC affect COPD course.