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Transport of minerals in renal tubules and its hormonal regulation

Fukumoto, S.

Clinical Calcium 17(5): 677-683

2007

ISSN/ISBN: 0917-5857
PMID: 17470995
Document Number: 605428
Mineral transport in renal tubules plays important role in the maintenance of serum concentrations of electrolytes. Filtered calcium from glomeruli is passively reabsorbed in proximal tubules and ascending limb of Henle. Calcium is further reabsorbed in distal tubules mainly mediated by transient receptor potential vallinoid 5 (TRPV5). Parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D stimulate this calcium reabsorption in distal tubules. Phosphate is reabsorbed in proximal tubules mediated by sodium-phosphate co-transporters. This proximal tubular phosphate reabsorption is inhibited by PTH and fibroblast growth factor (FGF) 23.

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