Role of cytokines in immune response to T-independent antigens, type 2
Borisova, T.K.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2006(1): 44-47
2006
ISSN/ISBN: 0372-9311 PMID: 16532640 Document Number: 605180
The influence. of human and mouse cytokines on the induction of immune response to model T-independent (TI) antigens of type 2 - DNP-dextran and DNP-ficoll - in the culture of mouse spleen cells was studied. For the first time this study revealed that the action of definite T-cell factors not only induced the polyclonal stimulation of B lymphocytes, but also the increased synthesis of specific antibodies, as well as switched over antibody isotypes from IgM to IgG. This confirmed the suggestion that T cells took part (directly or indirectly) in the regulation of immune response to so-called TI antigens. These results widened our knowledge on the mechanisms of the development of humoral immune response to TI antigens of type 2.