The regulation of the immune response to T-independent antigens by prostaglandins and B cells
Zimecki, M.; Webb, D.R.
Journal of Immunology 117(6): 2158-2164
1976
ISSN/ISBN: 0022-1767 PMID: 792340 Document Number: 100723
The effect of inhibitors of prostaglandin synthesis on the in vitro primary immune response to two T-independent antigens has been investigated. The results, with PVP or DNP-Ficoll, suggest that the prostaglandins play an important role in the regulation of the immune response to these antigens. Furthermore, it appears that B cells may be involved in their own regulation by synthesizing and responding to prostaglandins. Although it has been previously established that T cells exert a regulatory influence on the response to PVP and DNP-Ficoll, this is the first demonstration of an apparent B cell regulation of B cell function via the production of a specific hormone.