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Cell-mediated immune response in patients with type IIa, type IIb and type IV primary hyperlipoproteinaemia

Antonaci, S.; Jirillo, E.; Garofalo, A.R.; Polignano, A.; Resta, F.; Pugliese, P.; Capurso, A.; Bonomo, L.

Cytobios 54(218-219): 181-189

1988

ISSN/ISBN: 0011-4529
PMID: 3263908
Document Number: 319904
Plasma lipoproteins inhibit immune function. Polymorphonuclear cell (PMN) and monocyte activities, and pokeweed mitogen (PWM)-driven B cell differentiation in patients with type IIa, type IIb and type IV primary hyperlipoproteinaemia were evaluated. Evidence is provided for a selective impairment of these functional capacities in type IIa and type IIb hyperlipoproteinaemic patients, while immune repsonsiveness is unaffected in type IV primary hyperlipoproteinaemia. The data suggest a specific immune dysfunction in patients with type IIa and type IIb primary hyperlipoproteinaemia.

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