Effects of dehydroepiandrosterone-sulfate on sexual motivation in male mice with different psychoemotional statuses
Amikishieva, A.V.; Ovsiukova, M.V.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 92(10): 1212-1220
2006
ISSN/ISBN: 0869-8139 PMID: 17216718 Document Number: 604983
Effects of dehydroepiandrosterone-sulfate (10, 30 and 100 microg/kg, i.p.) on stability of sexual motivation of C57BL/6J male mice with different psychoemotional statuses were studied. Sexual motivation was assessed for 30 min in the sensory contact setting: a male was exposed to a female at oestrus from behind a perforated transparent partition which prevented physical contact. In the intact males, dehydroepiandrosterone-sulfate injection (10 and 30 microg/kg) 4 hrs before the test had no effect on parameters of sexual motivation. In aggressive males, administration of the dehydroepiandrosterone-sulfate had no effect on the intensity of the initial 10 min phase of sexual motivation but prevented its rapid decrease afterwards. In submissive mice, either dose reduced intensity of the initial phase of behavioral reaction to receptive female; however, tile higher dose prevented motivation from exhaustion, and so interest to the female was persistent, albeit decreased. The highest dose of dehydroepiandrosterone-sulfate had inhibitory effects on stability of the sexual interest in the male mice of all experimental groups.