Age-related characteristics of the regulation of the dehydroepiandrosterone sulfate level in the peripheral blood plasma of monkeys
Goncharova, N.D.
Biulleten' Eksperimental'noi Biologii i Meditsiny 116(12): 598-601
1993
ISSN/ISBN: 0365-9615 PMID: 8123814 Document Number: 408455
The author presents the results of study of dehydroepiandrosterone sulfate (DEAS) regulation in the circulation of male monkeys (P. hamadryas) of different age groups young nature, 8-10, and old, 26 y.o.) by functional tests with chorionic gonadotropin, and a sensitive and specific direct radioimmunoassay of plasma DEAS level developed by the author. It has established that ACTE is the principal regulator of DEAS secretion in young nature monkeys. The level of DEAS secretion in old monkeys. Testicular DEAS secretion was also notes in young animals during hyperactivation of gonadal function. The author proposes the presence of a spare mechanism of activation of testicular steroidogenesis in monkeys (through on of sulfate conjugative precursors synthesis and their transformation into testosterone) which plays an important role in the androgenopoiesis in old animals.