Evaluation of the antihypoxic activity of glycine and its phosphorylated derivative
Makarova, L.M.
Eksperimental'naia i Klinicheskaia Farmakologiia 69(3): 71-73
2006
ISSN/ISBN: 0869-2092 PMID: 16878506 Document Number: 604446
The antihypoxant activity of glycine and its phosphorilated derivative AKF 90-7 in doses 1, 20, 50 and 100 mg/kg was studied. AKF 90-7 increases the survival of laboratory animals under the conditions of various hypoxia types. The antihypoxic effect of glycine was the same with the effect of AKF 90-7 in hystotoxic hypoxia, but absent on the model of hermic hypoxia and substantially lower than that of AKF 90-7 on the models of hypercapnic and hypobaric hypoxia.