Leu-enkephalin modulates gastric secretion activated by various stimulants
Prosekina, E.Iu.; Tomova, T.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 69(3): 29-31
2006
ISSN/ISBN: 0869-2092 PMID: 16878495 Document Number: 604334
The results of chronic experiments on dogs showed that leu-enkephalin in doses 1, 7, and 9 mu g/kg produced different effects on the gastric secretion and excretion on the background of various stimulants. The maximum protective effect of opiate was produced in a dose of 7 mu g/kg. The peptide effect depended on the gastric secretion stimulator used: on the background of carbachol and pentagastrine, the activity of acidic and peptic factors was decreased and the protective factors of gastric juice were increased. In the case of histamine, leu-enkephalin increased the juice acidity and mucus secretion, but decreased the activity of pepsin and the excretion of ammonia from the stomach.