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The influence of leu-enkephalin on the bile secretion function in the rat liver during pharmacological modulation of the autonomous nervous system

Latyshenko, L.A.; Reshetnik, I.M.; Vesel's'kyĭ, S.P.; Makarchuk, M.I.

Fiziolohichnyi Zhurnal 55(3): 67-74

2009

ISSN/ISBN: 2522-9028
PMID: 19526858
Document Number: 630800
In acute experiments on rats the influence of ley-enkephalin (1 mkg/100 g) on liver bile secretion function and changes of organic contents of bile were studied. For studying the influence of opioid peptide under conditions of altered state of adreno- and cholinoreceptors, the antagonists of alpha- and beta-adrenoreceptors phentolamin (25 mkg/100 g) and obzidan (5 mkg/100 g), and the blocker of M-holinoreceptors atropine (2 mkg/100 g) were used. The pharmacological modulation of autonomous nervous systems alters the effects of ley-enkephalin on cholesecretions. Opioid peptide in the presence of antagonists of alpha-adrenoreceptors stimulates the processes of bile acids conjugation, in the presence of antagonists of beta-adrenoreceptors it cancels the effects of ley-enkephalin. The antagonists M-holinoreceptors reverse the effects of ley-enkephalin for the opposite ones: the synthesis and transport of free bile asides and cholisterine are suppressed.

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