Twenty-year remission of rheumatoid arthritis in 2 patients after allogeneic bone marrow transplant
Lowenthal, R.M.; Francis, H.; Gill, D.S.
Journal of Rheumatology 33(4): 812-813
2006
ISSN/ISBN: 0315-162X PMID: 16583483 Document Number: 603592
We describe 21 and 19 year followup of 2 patients with severe rheumatoid arthritis (RA) who in 1984 and 1986 underwent allogeneic bone marrow transplantation (BMT) after full myeloablative conditioning, for therapy-induced aplastic anemia. Regarding the arthritis, both patients are well, taking no medications, and free of signs or symptoms of active RA. One patient is in excellent health overall, while the other has coronary artery disease and chronic obstructive pulmonary disease attributable to smoking. We suggest that allogeneic BMT may be a curative treatment for severe RA.
Document emailed within 1 workday
Related Documents
Cooper, M.H.; Maraninchi, D.; Gastaut, J.A.; Mannoni, P.; Carcassonne, Y. 1993: HIV infection in autologous and allogeneic bone marrow transplant patients: a retrospective analysis of the Marseille bone marrow transplant population Journal of Acquired Immune Deficiency Syndromes 6(3): 277-284Sutton, L.; Kuentz, M.; Cordonnier, C.; Blaise, D.; Devergie, A.; Guyotat, D.; Leblond, V.; Flesch, M.; Bordigoni, P.; Attal, M. 1993: Allogeneic bone marrow transplantation for adult acute lymphoblastic leukemia in first complete remission: factors predictive of transplant-related mortality and influence of total body irradiation modalities Bone Marrow Transplantation 12(6): 583-589
Pons Romero, F.; Bruguera, M.; Bombi, J.A. 1986: A 29-year-old male with jaundice, abdominal pain and distension after a transplant of allogeneic bone marrow for acute leukemia Medicina Clinica 86(11): 472-479
Piatkin, E.K.; Baranov, A.E. 1977: Chromosome lesions caused by cyclophosphane in the bone marrow cells of a female aplastic anemia patient in the process of preparation for an allogeneic bone marrow transplant Problemy Gematologii i Perelivaniia Krovi 22(3): 12-16
Esteban, J.M.; Somlo, G. 1995: Skin biopsy in allogeneic and autologous bone marrow transplant patients: a histologic and immunohistochemical study and review of the literature Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology Inc 8(1): 59-64
Vannucchi, A.M.; Bosi, A.; Grossi, A.; Guidi, S.; Saccardi, R.; Lombardini, L.; Rossi-Ferrini, P. 1992: Stimulation of erythroid engraftment by recombinant human erythropoietin in ABO-compatible, HLA-identical, allogeneic bone marrow transplant patients Leukemia 6(3): 215-219
Tomita, T.; Kashiwagi, N.; Shimaoka, Y.; Ikawa, T.; Tanabe, M.; Nakagawa, S.; Kawamura, S.; Denno, K.; Owaki, H.; Ochi, T. 1994: Phenotypic characteristics of bone marrow cells in patients with rheumatoid arthritis Journal of Rheumatology 21(9): 1608-1614
Rønnov-Jessen, D.; Løvgreen Nielsen, P.; Horn, T. 1991: Persistence of systemic mastocytosis after allogeneic bone marrow transplantation in spite of complete remission of the associated myelodysplastic syndrome Bone Marrow Transplantation 8(5): 413-415
Torres, A.; Martínez, F.; Gómez, P.; Fornés, G.; Rojas, R.; Herrera, C.; Gómez, J.L.; Manzanares, R.; García, J.M.; Andres, P. 1989: Allogeneic bone marrow transplantation versus chemotherapy in the treatment of childhood acute lymphoblastic leukemia in second complete remission Bone Marrow Transplantation 4(6): 609-612
Böcher, W.O.; Schirmacher, P.; Löhr, H.F.; Kolbe, K.; Wanitschke, R.; Meyer zum Büschenfelde, K.H. 1995: Hepatic manifestation of hemolytic uremic syndrome in an allogeneic bone marrow transplant recipient Zeitschrift für Gastroenterologie 33(9): 543-545
Jäntti, J.; Kaarela, K.; Kautiainen, H.; Isomäki, H.; Aho, K. 2001: Radiographic remission in seropositive rheumatoid arthritis. a 20-year follow-up study Clinical and Experimental Rheumatology 19(5): 573-576
Drobyski, W.R.; Roth, M.S.; Thibodeau, S.N.; Gottschall, J.L. 1992: Molecular remission occurring after donor leukocyte infusions for the treatment of relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation Bone Marrow Transplantation 10(3): 301-304
Yu, C.; Li, M.; Duan, X.; Fang, Y.; Li, Q.; Wu, R.; Liu, S.; Wang, Y.; Wu, Z.; Shi, X.; Jiang, Z.; Wang, Y.; Hsieh, E.D.; Jin, S.; Jiang, N.; Wang, Q.; Zhao, Y.; Tian, X.; Zeng, X. 2018: Chinese registry of rheumatoid arthritis (CREDIT): I. Introduction and prevalence of remission in Chinese patients with rheumatoid arthritis Clinical and Experimental Rheumatology 36(5): 836-840
Gómez-Casares, M.T.; Naranjo, A.; Campo, C.; Mataix, R.; Guerra, L.; Suarez, A.; Malcorra, J.J. 1995: Another case of pneumococcal arthritis after allogeneic bone marrow transplantation Bone Marrow Transplantation 15(4): 650
Dotti, G.; Gaspari, F.; Caruso, R.; Perico, N.; Remuzzi, G.; Barbui, T.; Rambaldi, A. 2001: Pharmacokinetic study of the new cyclosporine-A formulation (Neoral) in adult allogeneic bone marrow transplant recipients Haematologica 86(3): 311-315
Marinone, M.G.; Paganelli, C.; Ferremi, P.; Rossi, G.; Izzi, T. 1991: Aggressive ulcerous stomatitis due to the herpes simplex virus in an allogeneic bone marrow transplant. a clinical case Minerva Stomatologica 40(7-8): 499-503
Irlé, C.; Kaestli, M.; Chapuis, B.; Jeannet, M. 1985: In vivo detection of alloreactive T cells of host origin after rejection of HLA-identical allogeneic bone marrow transplant Schweizerische Medizinische Wochenschrift 115(43): 1525-1526
Moussalem, M.; Esperou Bourdeau, H.; Devergie, A.; Baruchel, A.; Ribaud, P.; Socie, G.; Parquet, N.; Traineau, R.; Hirsch, I.; Schaison, G. 1995: Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission: factors predictive of survival, relapse and graft-versus-host disease Bone Marrow Transplantation 15(6): 943-947
Bacigalupo, A.; Frassoni, F.; Van Lint, M.T.; Occhini, D.; Gualandi, F.; Lamparelli, T.; Vitale, V.; Scarpati, D.; Clavio, M.; Marmont, A.M. 1989: Allogeneic bone marrow transplantation in acute and chronic myeloid leukemia: role of conditioning and of graft-versus-host disease in the long-term maintenance of remission Haematologica 74(5 Suppl): 425-432
Bursztyn, M.; Zelig, O.; Or, R.; Nagler, A. 1997: Isradipine for the prevention of cyclosporine-induced hypertension in allogeneic bone marrow transplant recipients: a randomized, double-blind study Transplantation 63(7): 1034-1036