Chinese registry of rheumatoid arthritis (CREDIT) : I. Introduction and prevalence of remission in Chinese patients with rheumatoid arthritis
Yu, C.; Li, M.; Duan, X.; Fang, Y.; Li, Q.; Wu, R.; Liu, S.; Wang, Y.; Wu, Z.; Shi, X.; Jiang, Z.; Wang, Y.; Hsieh, E.D.; Jin, S.; Jiang, N.; Wang, Q.; Zhao, Y.; Tian, X.; Zeng, X.
Clinical and Experimental Rheumatology 36(5): 836-840
2018
ISSN/ISBN: 0392-856X PMID: 29600939 Document Number: 695015
To introduce the Chinese Registry of rhEumatoiD arthrITis (CREDIT), which is the first nationwide, multicentre, online rheumatoid arthritis (RA) registry in China, and to depict major cross-sectional data and treatment strategies of Chinese RA patients. RA patients who fulfilled the 2010 ACR/EULAR classification criteria for rheumatoid arthritis were recruited into the registry by their rheumatologists from 144 clinical centres in China. Data, including demographics, disease characteristics, co-morbidities, treatment, and adverse reactions, were collected and documented through the predefined protocol. 8071 registered patients (F:M = 4.03:1) were registered up to May 2017. Mean age at symptom onset and at diagnosis was 46.15±14.72y and 48.68±14.54y, respectively. Point prevalence of remission (95% CIs) was 14.88% (14.10-15.66%), 4.23% (3.79-4.66%), 4.25% (3.81-4.69%), and 4.27% (3.83-4.72%) according to DAS28-CRP, CDAI, SDAI, and the 2011 ACR/EULAR remission criteria, respectively. 38.84% and 38.11% of treatment-naïve patients (n=3262) were in moderate (3.2<DAS28-CRP≤5.1) and high (DAS28-CRP>5.1) disease activity, respectively. Among treatment-naïve patients, those who were initiated on treatment with bDMARDs had higher disease activity than those who were treated with csDMARDs (p<0.05). Three months after initiating bDMARDs, 19.29% (n=38) of patients achieved remission (DAS28-CRP<2.6). The CREDIT registry is an effective tool for real-world study of RA patients in China. By providing information for diagnosis and treatment regimen, the CREDIT registry can enhance the application of treat-to-target (T2T) strategy and improve patient outcomes in China.