Microscopic polyangiitis associated with primary biliary cirrhosis: a causal or casual association?

Amezcua-Guerra, L.M.; Prieto, P.; Bojalil, R.; Pineda, C.; Amigo, M-Carmen.

Journal of Rheumatology 33(11): 2351-2353

2006


ISSN/ISBN: 0315-162X
PMID: 16981285
Document Number: 603506
The association between microscopic polyangiitis (MPA) and primary biliary cirrhosis (PBC) has seldom been reported. We describe a patient with PBC and MPA who presented with polyarthritis and pulmonary nodules followed by pauci-immune crescentic glomerulonephritis and liver dysfunction. Detection of p-ANCA, antimyeloperoxidase, and antimitochondrial antibodies along with liver and renal histopathology allowed a diagnosis of MPA and PBC. We also discuss 2 other cases that could be unrecognized associations of both diseases. Further reports are necessary to clarify if the coexistence between PBC and MPA is causal or casual.

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