Primary biliary cirrhosis and coeliac disease: an association?
Logan, R.F.; Ferguson, A.; Finlayson, N.D.; Weir, D.G.
Lancet 1(8058): 230-233
1978
ISSN/ISBN: 0140-6736 PMID: 74661 Document Number: 138587
The association of primary biliary cirrhosis and coeliac disease, not previously reported, was observed in 4 patients. In each case, the two conditions were diagnosed simultaneously, and although symptoms were due to coeliac disease, initial investigation drew attention to the liver condition. All the patients responded to a gluten-free diet and remain well 2 years later. Primary biliary cirrhosis remains asymptomatic in 3 patients, but pruritus has developed in the 4th. The significance of this association is unclear and may merit formal study. Coeliac disease should be considered as a possible cause of unexplained weight loss in primary biliary cirrhosis.