Antifungal susceptibility testing of commensal and pathogenic clinical isolates of oral Candida
Zhao, M.; Zhou, Z.-t.
Shanghai Kou Qiang Yi Xue 15(2): 218-220
2006
ISSN/ISBN: 1006-7248 PMID: 16685371 Document Number: 602959
To evaluate and compare the sensitivity and resistance of commensal and pathogenic oral Candida to antifungal agents. YBC Test Kit was used to identify species of commensal and pathogenic oral Candida; The in vitro susceptibilities of oral Candida to 5-flucytosine (5-FC), itraconazole (ITR) and fluconazole (FLU) were determined by NCCLS M27-A2 method. All strains were sensitive to 5-flucytosine, drug resistant strains to fluconazole and itraconazole were found both in commensal and pathogenic oral Candida spp; The proportion of no-C. albicans and antifungal drug resistant strains isolated from head and neck cancer patients treated with radiotherapy or chemotherapy were higher than oral commensal Candida and oral Candidiasis. The no-C. albicans and drug resistant strains to fluconazole and itraconazole can be found both in commensal and pathogenic oral Candida spp now.