Antifungal susceptibility of non-albicans Candida species causing fingernail onychomycosis
Upton, A.; Rogers, K.; Wood, N.; Morris, A.J.
New Zealand Medical Journal 117(1201): U1060
2004
ISSN/ISBN: 0028-8446 PMID: 15476017 Document Number: 582506
Susceptibility testing on 34 non-albicans isolates recovered from fingernails was performed (New Zealand): C. parapsilosis (22), C. tropicalis (5), C. lusitaniae (2), and 5 other species. All isolates were resistant to griseofulvin and susceptible to clotrimazole and nystatin. All but one isolate, C. parapsilosis, were susceptible to flucytosine. There are no interpretative criteria for ketoconazole and voriconazole; all the MICs for these agents were less than or equal to 2 mg/litre, with MIC90 of 0.03 mg/litre and 0.125 mg/litre, respectively. The majority (94%) of isolates were susceptible to fluconazole. Terbinafine resistance was seen in 5 (15%) isolates and intermediate susceptibility in 4 (12%). No isolate was resistant to itraconazole but 8 (24%) had reduced susceptibility (dose-dependent).