The effect of the time of death on the reactivity of rat caudal artery regulated by NA with a simultaneous use of NOS, CG and COX inhibitors. Part i
Bloch-Bogusławska, E.
Archiwum Medycyny Sadowej i Kryminologii 56(3): 136-143
2006
ISSN/ISBN: 0324-8267 PMID: 17131756 Document Number: 601609
The investigations were carried out on NA-perfused rat caudal arteries in four different time groups. Inhibitors of NO synthase, CG and COX were used simultaneously to explain the effect of the time of death on biochemical mechanisms regulating the function of metabotropic receptors. The study demonstrated that using the NO synthase inhibitor improved post mortem arterial reactivity, what indicated maintained endogenous NO synthesis after death. The CG inhibitor was also found to improve arterial reactivity and intracellular Ca++ ion concentration. No improvement in arterial reactivity was observed when COX was used in the experiment.