Long-term hydroxyurea treatment in children with sickle cell disease: tolerance and clinical outcomes
de Montalembert, M.; Brousse, V.; Elie, C.; Bernaudin, Fçoise.; Shi, J.; Landais, P.
Haematologica 91(1): 125-128
2006
ISSN/ISBN: 0390-6078 PMID: 16434381 Document Number: 601222
Two hundred twenty-five SCD children have been enrolled in a study assessing the tolerability of hydroxyurea treatment. Mean age at inclusion was 9.2 +/- 4.4 years, median duration of treatment was 3.8 years. Ten and 75 patients have been treated respectively for more than 10 and 5 years. No severe side effect was related to hydroxyurea treatment, which was discontinued in 81 children mainly for treatment failure (30 cases) or non-compliance (17 cases). Treatment was also withdrawn in 5 of 6 children who had developed hypersplenism, in 3 because of a pathological transcranial Doppler, and in 2 after a stroke.