Multiple squamous cell carcinomas of the skin during long-term treatment with hydroxyurea
De Simone, C.; Guerriero, C.; Guidi, B.; Rotoli, M.; Venier, A.; Tartaglione, R.
European Journal of Dermatology Ejd 8(2): 114-115
1998
ISSN/ISBN: 1167-1122 PMID: 9649662 Document Number: 494099
Hydroxyurea is a chemotherapeutic agent used extensively for myeloproliferative disorders. Cutaneous side effects have been described during long-term hydroxyurea treatment. We described the occurrence of multiple squamous cell skin carcinomas in a patient treated with hydroxyurea for chronic myelogenous leukemia. The lesions were removed and the hematological therapy switched to busulfan. In a previously reported case, the development of cutaneous epithelial cancers required the discontinuation of hydroxyurea, in addition to the surgical excision of the neoplastic lesions. Since squamous cell carcinoma is a malignant cutaneous neoplasm that can metastatize, the surveillance of skin changes is advisable during hydroxyurea treatment.