Exacerbation of tonicoclonic seizures in a juvenile myoclonic epileptic taking lamotrigine
Maiga, Y.; Nogues, B.; Guillon, B.
Revue Neurologique (Paris) 162(11): 1125-1127
2006
ISSN/ISBN: 0035-3787 PMID: 17086150 Document Number: 599907
Introduction. Lamotrigine is an anti-epileptic drug considered as a first-line therapy in idiopathic generalised epilepsy. Lamotrigine is well-tolerated and secondary aggravation of epileptic syndromes has rarely been reported. Case report. We report the case of a 19 year-old man with juvenile myoclonic epilepsy in whom lamotrigine lead to the exacerbation of generalised tonico-clonic seizures, reversible when lamotrigine was stopped and substituted by valproic acid. Conclusion. Lamotrogine may induce exacerbation of generalised tonico-clonic seizures and myoclonic jerks in juvenile myoclonic epilepsy.