The nerve growth factor induces cutaneous ulcer healing in "non-responder" tranplanted skin
Tuveri, M.A.; Triaca, V.; Aloe, L.
Annali Dell'istituto Superiore di Sanita 42(1): 94-96
2006
ISSN/ISBN: 0021-2571 PMID: 16801731 Document Number: 599652
Nerve growth factor (NGF) is an endogenously produced growth factor regulating survival not only of nerve cells, but also of cutaneous tissues. We have recently reported that NGF can promote healing of human corneal ulcer, and cutaneous diabetic and pressure ulcers. In this study, we present a case report showing that NGF can induce recovery of a chronic cutaneous ulcer that failed to respond to all available therapies, including autologous skin transplantation. The result showed that topical application of NGF for 3 consecutive months induced skin ulcer healing and reduced the local inflammation. This finding supports and extents previous studies suggesting the cutaneous healing action and the potential therapeutic role of NGF.