Profiling of metal ions leached from pharmaceutical packaging materials
Fliszar, K.A.; Walker, D.; Allain, L.
PDA Journal of Pharmaceutical Science and Technology 60(6): 337-342
2006
ISSN/ISBN: 1079-7440 PMID: 17260898 Document Number: 599525
Metal leachables from packaging components can affect the safety and efficacy of a pharmaceutical formulation. As liquid formulations continue to contain surfactants, salts, and chelating agents coupled with lower drug levels, the interaction between the formulation and the packaging material becomes more important. This study examines the interaction of commonly used packaging materials with extraction solvents representative of liquid formulations found in the pharmaceutical industry stressed under conditions encountered during accelerated stability studies.
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