Rare earth metal ions for unprecedentedly fast RNA hydrolysis
Matsumura, K.; Matsumoto, Y.; Komiyama, M.
Nucleic Acids Symposium Series 27: 11-12
1992
ISSN/ISBN: 0261-3166 PMID: 1283899 Document Number: 392887
Adenylyl(3'-5')adenosine (ApA) and uridyl(3'-5')uridine (UpU) are hydrolyzed at unprecedentedly large rates by rare earth metal ions at pH 8, 30 degrees C. With 0.01 M Tm(III), the half-lives are 10 min and 51 min, respectively. Potentiality of these ions as catalytic center of artificial ribonuclease is proposed.