Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases
Canedo-Patzi, A.M.; León-Bojorge, B.; de Ortíz-Hidalgo, C.
Gaceta Medica de Mexico 142(1): 59-66
2006
ISSN/ISBN: 0016-3813 PMID: 16548294 Document Number: 598842
Describe the histological andimmunohistochemicalfeatures of nine genital tract adenomatoid tumors. Nine cases of adenomatoid tumors were collected from the files of the Pathology department at a private hospital (ABC Hospital). Tumors were studied from a histological and inmunohistochemical perspective. Eight women and one man were studied. Age range was 28-54 yrs. Tumors were located in the uterus (seven),fallopian tube (one) and epididymis (one). Tumor size ranged from 0.4 to 5.8 cm. We observed three histological patterns: adenoid, angiomatoid and solid. Arrangement of the neoplastic tubules around fascicles of smooth muscle; angiomatoidpattern with a peripheral location, and solid and adenoidpatterns with a central location in the tumor were some of the observed histological features. Immunohistochemically all tumors exhibited strong and diffuse positivity for calretinin and AE1/AE3. Thrombomodulin was positive in all tumors (focal and weak in angiomatoid pattern and diffuse and strong in adenoid and solid patterns). The CK5/6 antibody was positive in seven tumors (diffuse in three and focal in four). Two tumors were negative for this marker. All tumors were negative for CD31. The immunopheno type of the adenomatoid tumors in our series confirms their mesothelial origin.